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History (7)
Department of Defense Idea Award
Principal Investigator
Resident Decision Making: Opioids in the Outpatient Setting.
Treatment of head and neck cancer with intra-arterial cytotoxic drugs and radiotherapy.
Case 4: Delayed Passage of Meconium, Abdominal Distention, and Emesis in a 2-day-old Girl.
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Rhodes, Christopher
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Rhodes, Christopher
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Concept
Protein Biosynthesis
Academic Article
Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation.
Academic Article
Cooperativity between the preproinsulin mRNA untranslated regions is necessary for glucose-stimulated translation.
Academic Article
Succinate is a preferential metabolic stimulus-coupling signal for glucose-induced proinsulin biosynthesis translation.
Academic Article
Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin.
Academic Article
A cis-element in the 5' untranslated region of the preproinsulin mRNA (ppIGE) is required for glucose regulation of proinsulin translation.
Academic Article
Exendin 4 controls insulin production in rat islet beta cells predominantly by potentiation of glucose-stimulated proinsulin biosynthesis at the translational level.
Academic Article
Effects of glucose and D-3-hydroxybutyrate on human pancreatic islet cell function.
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Protein Biosynthesis